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Antimicrobial assay Antibacterial assay
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Community analysis Heterologous expression system in vivo model Microbe-host interactions Microbial biochemistry Microbial biofilm Microbial cell biology Microbial genetics Microbial metabolism Microbial physiology Microbial proteomics Microbial signaling Pathogen detectionLuminescence-based Antiviral Assay for Hepatitis E Virus
Hepatitis E virus (HEV) is one of the main causes of acute hepatitis worldwide. Infections are particularly severe in pregnant women and chronic hepatitis E is known to occur in immunocompromised patients. Current therapy (ribavirin or pegylated alpha interferon) has severe side effects and cannot be employed in all patients. In order to evaluate potential new inhibitors of HEV replication, a luminescence-based replicon assay is particularly useful since it offers a rapid read-out and does not pose any biosafety risks (Debing et al., 2014).